Variations in pulmonary antibacterial defenses among experimental animals

Pulmonary antibacterial defenses during mild and severe influenza virus infection.

Severe influenza virus infections with pneumonic involvement are known to predispose the lungs to bacterial superinfections due to dysfunctions in the alveolar macrophage (AM) phagocytic system. To determine whether milder forms of influenza without pneumonic involvement have a similar outcome, pulmonary antibacterial defenses and AM phagocytosis were compared in murine models of mild and sever...

Scorpion Venom Pisoning in Experimental Animals

Pulmonary host defenses and alcohol.

Alcohol abuse is a major risk factor for the development of many infectious diseases, particularly pulmonary infections. Bacterial pneumonia and other lung infections in alcohol-abusing patients are usually severe and associated with a high morbidity and mortality. Normal host defense mechanisms in the respiratory tract consist of both innate and acquired immunity which operate effectively in p...

Molecular and structural antioxidant defenses against oxidative stress in animals.

In this review, it is our aim 1) to describe the high diversity in molecular and structural antioxidant defenses against oxidative stress in animals, 2) to extend the traditional concept of antioxidant to other structural and functional factors affecting the "whole" organism, 3) to incorporate, when supportable by evidence, mechanisms into models of life-history trade-offs and maternal/epigenet...

Strategies for Antibacterial Treatment in Small Animals

INTRODUCTION Antibiotic therapy has made many advances that has given veterinary medicine a large number of effective drugs and provided pharmacokinetic and pharmacodynamic information to guide dosing. Improved techniques for bacterial identification and susceptibility testing have helped to provide information for the most appropriate drug selection. This presentation will review the current c...